The VIIth 
Complement Genetics Workshop 
and Conference 
Mainz, May 21 - 23, 1998

• Location
• Attendance
• Final Programme
• Abstract List
• Publications
• The Participants

Thursday, May 21 

• Meetings of the Reference Typing Groups for CR1, C6-C7-C9, C4
• C.A. Alper (Boston): The history of complement genetics

• C.Y. Yu (Columbus): Genetics and evolution of the MHC-linked complement gene cluster: from C2 to TNX
• Session M: Molecular Genetics, Polymorphism, Deficiency and Evolution 
• Session P:  Populations Genetics 
• M. J. Hobart (Leicester): Ancient and modern evolution of the membrane attack complex genes"
• Y. Fukumori (Osaka): Terminal complement component deficiencies in Japan
• Reference Typing Summaries from the working groups

• M. C. Carroll (Boston): Transgenic and knockout animals as model systems to study complement gene function
• M. Botto (London): C1 knockout mice for the study of complement deficiency in autoimmune disease
• Session D: Complement Genetics and Disease
• Session R: Regulators of Complement Activation
• J.P. Atkinson (St. Louis): Conference Summary

1. Dawkins RL*, Martinez OP, Balmer L, Kulski J, Leelayuwat C, Gaudieri S, Giles K, Cattley S, Tay GK. Evolution, segmental duplication and polymorphisms of MHC-linked complement genes.
2. Paz-Artal E*, Corell A, Alvarez M, Allende L, Varela P, Marrinez-Laso J, Martin-Villa M, Morales P, Arnaiz-Villena A. Molecular evolution of complement genes in primates.
3. Jaatinen T*, Ruuskanen O, Repo H, Lokki ML. Deletions and nonfunctional genes in the RP-C4-CYP21-TNX gene region.
4. Yang Z*, Yu CY. Four ubiquitously expressed genes between human complement factor B and C4 in the HLA.
5. Witzel-Schlömp K*, Rittner C, Schneider PM. DNA polymorphisms in the human complement C9 gene.
6. Bellavia D, Amodeo G, Schneider PM, Brai M C8ß deficiency: report of an Italian family.
7. Kaufmann T, Rittner C, Stradmann-Bellinghausen B, Zhang L, Orren A, Schneider PM. Genetic basis and epidemiology of human complement C8ß deficiency in Caucasians.
8. Schneider PM, Gesierich T, Zhang L, Stradmann-Bellinghausen B, Kaufmann T, Rittner C. Molecular basis of human complement C8A polymorphism.
9. Fernie BA, Hobart MJ. C7 deficiency: seven further molecular defects and their associated marker haplotypes, including five new polymorphisms.
10. Hobart MJ, Fernie BA, Fijen CAP, Orren A. The molecular bases of C6 deficiency in the Western Cape, South Africa.
11. Frank A, Stradmann-Bellinghausen B, Schneider PM, Rittner C, Höhler T. Molecular basis of several rare variants of human complement component C3. 
12. Santos P, Breda-Coimbra H. Simple and rapid one-step typing method for codon 7 of the human factor B using sequence-specific primers (PCR-SSP).
13. Witzel-Schlömp K, Stradmann-Bellinghausen B, Moulds JM, Bontrop R, Schneider PM. Comparative phylogenetic analysis of C4 genomic sequences outside the isotype-specific region in primates.
14. Fredrikson GN, Gullstrand B, Schneider PM, Witzel-Schlömp K, Sjöholm AG, Alper CA, Awdeh Z, Truedsson L. Characterization of non-expressed C4 genes in a case of complete C4 deficiency: identification of a novel point mutation leading to a premature stop codon. 
15. Rupert KL,  Moulds JM, Wells TD,  Blanchong CA, Yu CY. Demonstration of C4A genes in the long, short, first and second C4 loci of the RCCX modules in the HLA class III region.
16. Petry F, Kabel PJ, Braaisma J, Daha MR, Loos M. A further case of hereditary C1q deficiency in a Turkish family from the Netherlands: analysis of the defective gene and mRNA.
17. Zhang L, Stradmann-Bellinghausen B, Rittner C, Schneider PM. Genetic polymorphism of human complement factor I in the Chinese Han  population.
18. Arason GJ, Kolka R, Kramer J, Arnason A. Quantitative and qualitative aspects of complement in healthy individuals with and without C4 null alleles.
19. Weg-Remers S,Brenden M, Schwarz E, Witzel-Schlömp K, Schneider PM, Guerra LK, Rehfeld IR,Lima MT, Hartmann D, Petzl-Erler ML, de Messias IJT, Mauff G. Genetics of major histocompatibility complex (MHC) class III complement components in two Amerindian tribes from Southern Brazil: the Kaingang and the Guarani.
20. Capelli E, Rossi A, Cortalezzo A, Degioanni A, Cuccia MC. Genetic structure of Piacenza province through C4 and classical HLA gene multivariate analysis.
21. Metin A, Sanal Ö, Ersoy F, Tezcan I, Berkel A. Polymorphism of complement C4 in the Turkish population.
22. Bellavia D, Amodeo G, Accardo P, Marcenò R, Brai M. Complotypes and extended haplotypes in healthy Sicilians.
23. Brai M, Bellavia D, Di Bona D, Accardo P, Natoli D Complement deficiencies in Sicily.
24. Rupert KL*, Rennebohm R, Yu CY. DNA recombination results in novel HLA haplotype detected in patient with juvenile rheumatoid arthritis.
25. Orisio S*, Noris M, Zipfel PF, Ruggenenti P, Perna A, Caprioli J, Vasile B, Skerka C, Remuzzi G. Hypocomplementemia discloses genetic predisposition to hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: role of factor H abnormalities.
26. Srivastava LM, Arora M*, Kumar A, Das SN. Complement regulatory protein deficiencies and activation of complement cascade on erythrocytes from patients with Rheumatoid Arthritis.
27. Brai M*, Accardo P, Clemenza L, Loria G, Giammanco A. Non opsonic binding of M. tuberculosis to CR1.
28. Oudin S, Lepennec PY, Dervillez X, Tonye-Libyh M, Tabary T, Philbert F, Bougy F, Reveil B, Pennaforte JL, Rouger P, Cohen JHM*. No quantitative relationship between CR1 and Lutheran (CD44 isoform) expression on erythrocytes: In (lu) or X2S gene products are not common regulators of CR1 and Lu expression on erythrocytes.
29. Moulds JM*, Zimmermann P. CR1 blood group polymorphisms and P. falciparum malaria.
30. Baumann U, Verbeek JS, Schmidt RE, Gessner JE*. FcGamma RIII and complement contribute differentially to immune complex mediated inflammation.
31. Kemper C*, Gigli I, Zipfel P. Ancestor precursor protein to the human plasma complement regulatory proteins factor H and C4 binding protein.
32. Hellwage J, Zipfel P. Multifunctional proteins of the factor H family: conservation of functional domains.
33. Colletti I, Clemenza L, Amodeo G, Bellavia D, Brai M. Frequency distribution of CR1 alleles in healthy Italians.
34. Moulds JM, Arnett FC, Reveille JD, Wu GG, Lin M. Ethnic variability in the frequency of CR1 structural alleles.
35. Accardo P, Amodeo G, Bellavia D, Napolitano S, Brai M. Mannan binding lectin (MBL) deficiency and C4 allotypes in upper respiratory tract infections.
36. Martinetti M, Dugoujon JM, Cortalezzo A, Luisetti M, Cuccia MC. HLA-class III (C4, Bf) and IgG (Gm, Km) gene interactions in sarcoidosis.
37. Kristjansdottir H, Steinsson K, Bjarnadottir, Hjalmarsdottir I, Gunnlaugsdottir B, Arnason A. MHC extended haplotypes in Icelandic multiplex SLE families.
38. Arora M, Srivastava LM, Dinda AK, Tiwari SC. Expression of complement regulatory proteins in minimal change nephrotic syndrome.
39. Würzner R, Dierich MP, Orren A. Phenotypic heterogeneity of complement C7 deficiencies. 

Schneider PM, Rittner C, Mauff G, Würzner R (Eds.): Proceedings of the VIIth Complement Genetics Workshop and Conference, Mainz, 1998. 
Exp. Clin. Immunogenet. 15:201-294, 1998 

• Schneider, P.M.; Rittner, C.; Mauff, G.; Würzner, R.: Editorial
• Alper, C.A.: A History of Complement Genetics
• Yu, C.Y: Molecular Genetics of the Human MHC Complement Gene Cluster
• Botto, M.: C1q Knock-Out Mice for the Study of Complement Deficiency in Autoimmune Disease
• Hobart, M.J.: Evolution of the Terminal Complement Genes: Ancient and Modern 
• Fukumori, Y.; Horiuchi, T.: Terminal Complement Component Deficiencies in Japan 
• Mauff, G. et al.: Reference Typing Report for Complement Component C4
• Geserick, G. et al.: Reference Typing Report for Complement Factor B
• Rittner, C. et al.: Reference Typing Report for Complement Component C3
• Würzner, R. et al.: Reference Typing Report for Complement Components C6, C7 and C9 Including Mutations Leading to Deficiencies
• Geserick, G.; Schröder, H.; Correns, A.: Reference Typing Report for Complement Component C6: Protein Typing
• Moulds, J.M. et al.: Reference Typing Report for Complement Receptor 1 (CR1)