Chromosomal Localisation of Complement Genes and Linkage Groups

 
Component (or subunit) Gene symbol Chromosomal location
C1q: a chain C1QA 1p34.1-p36.3
C1q: b chain C1QB 1p34.1-p36.3
C1q: g chain C1QG 1p34.1-p36.3
C8: a chain C8A 1p32
C8: b chain C8B 1p32
C4 Binding Protein: a chain C4BPA 1q32 (a)
C4 Binding Protein: b chain C4BPB 1q32 (a)
Complement Receptor 1 (CD 35) CR1 1q32 (a)
Complement Receptor 2 (CD 21) CR2 1q32 (a)
Decay Accelerating Factor (CD 55) DAF 1q32 (a)
Membrane Cofactor Protein (CD 46) MCP 1q32 (a)
Factor H HF 1q32 (a)
Factor I IF 4q25
C6 C6 5p13 (b)
C7 C7 5p13 (b)
C9 C9 5p13 (b)
C2 C2 6p21.3 (c)
Factor B BF 6p21.3 (c)
C4A (isotype) C4A 6p21.3 (c)
C4B (isotype) C4B 6p21.3 (c)
C8: g chain C8G 9q22.3-q32
C5 C5 9q33
Mannose Binding Lectin MBL 10q11.2-q21
Perforin PRF1 10q22
Surfactant Proteins A1 and A2 SFTPA1, A2 10q22-q23
Surfactant Protein D SFTPD 10q22-q23
Membrane Inhibitor of Reactive Lysis  
(MIRL, CD59)
CD59 11p13
C1 Inhibitor C1NH 11q11-q13.1
C1r C1R 12p13
C1s C1S 12p13
Complement Receptor 3: a chain,  
= a-M Integrin (CR3A, CD11A)
ITGAM 16p11.2
Vitronectin (S-protein) VTN 17q11
C3 C3 19p13.3-p13.2
C5a receptor 1 C5R1 19q13.3-q13.4
Leucocyte Adhesion Molecule: b chain,  
= b-2 Integrin (LCAMB, CD18)
ITGB2 21q22.3
Properdin PFC Xp11.4-p11.2
 
Footnotes: (a) Regulators of complement activation (RCA) gene cluster
(b) Membrane attack complex (MAC) gene cluster
(c) MHC class III complement gene cluster
 
The Complement Genetics Homepage in Mainz: Chromosomal locations (last update: July 7, 1999)