The VIth Complement Genetics Workshop 
and Conference 
Mainz, July 27 - 29, 1989

• Location
• Attendance
• Final Programme
• Abstract List
• Publications
• The Participants

Thursday, July 27, 1989 (Institute of Legal Medicine) 

• Workshop Discussion: Presentation of Reference Typing Results by the Reference Typing Laboratories

• Evening Tour: Rhine River Cruise with Dinner 

• Welcome Address: Vice President of the Johannes Gutenberg University Mainz, Prof.Dr. E.J. Zöllner
• Scientific Session I: C4 POLYMORPHISM - GENE STRUCTURE AND ORGANIZATION IN MAN AND ANIMALS

1. R.D. Campbell, Oxford: "Molecular characterization of the MHC class III region"
2. Short presentations
• Scientific Session II: STRUCTURE AND FUNCTION OF MHC-LINKED GENES

1. H.R. Colten, St. Louis: "Genetic and tissue-specific control of C2 and factor B transcription"
2. Short presentations
• Scientific Session III: C8 POLYMORPHISM - GENE STRUCTURE AND FUNCTION

1. J.M. Sodetz, Columbia: "Structural analysis of the human C8 alpha gene and its linkage to C8 beta"
2. Short presentations
• Poster Demonstration & Discussion: R.L. Dawkins, Perth (Chairman)

• Evening tour: Romantic Dinner at Kropsburg Castle

• Scientific Session IV: STRUCTURE AND POLYMORPHISM OF NON-MHC-LINKED COMPLEMENT GENES

1. C.A. Alper, Boston: Introduction
2. Short presentations
• WORKSHOP REPORT SESSION (Chairman: G.J. O'Neill)

Summaries of Reference Typing Reports:
• CR1 / MCP: J.P. Atkinson, St. Louis
• C4: G. Mauff, Cologne
• BF: G. Geserick, Berlin
• C2: G. Hauptmann, Strasbourg
• C3: C. Rittner, Mainz
• C6: K. Tokunaga, Tokyo
• C7: M. Hobart, Cambridge
• C8: S. Rogde, Oslo
• Factor I: S. Nakamura, Tokyo

• Concluding remarks: P.J. Lachmann, Cambridge

1.  Amendoeira R, Guilherme L, Marin M, *Taborda de Messias I, Marzochi M, Kalil J.  HLA and visceral leishmaniasis.
2. *Berg ES, Markussen G, Teisberg P, Olaisen B; Oslo: Direct DNA sequencing of PCR products of C4 alleles.
3. *Berg ES, Teisberg P, Olaisen B.  Analysis of C4 polymorphism by use of DNA amplification (PCR), allele-specific oligonucleotide probes and allele specific restriction enzymes.
4. Braun L, *Schneider PM, Giles CM, Susemichel-Hüppner A, Bertrams J, Rittner C; Mainz: Structural analysis of complement C4 null alleles reveals pseudogenes at the C4A locus and gene conversion at the C4B locus.
5. Wang Ce, *Yao Zhu, Wu Xong-Wen, Zhao Xiu-Zhu. Determination of complotype frequencies in patients with systemic lupus erythematosus (SLE).
6. *Chrispeels J, Bank S, Rittner C, Bitter-Suermann D.  Quantification of C4A and C4B isotypes in human plasma by sandwich enzyme-linked immunosorbent assays.
7. Cobain TJ, Dawkins RL, *Christiansen FT.  A report on the complement allotyping exchange for the fourth Asia-Oceania Histocompatibility Workshop.
8. *Coimbra H.B, Santos P, Oliveira M.F.  MHC class III antigen (BF,C2 and C4) polymorphism in Portugal.
9. *Dawkins RL, Christiansen FT; Perth: Complement allotyping, ancestral haplotypes and autoimmune disease.
10. Doxiadis I, Rebmann V, Grosse-Wilde H.  Quantification of the complement components C4A and C4B and their relationship to allotyping, Q0 deifinition, and to duplication.
11. *Finco O, Mantovani V, Busachi CA, Manghi I, Cuccia M.  C4 null alleles and unresponsiveness to HB vaccine.
12. *Fraser PA, Coughlin B, Stein R, Bagley D, Johnson A, Yunis E, Awdeh Z, Alper CA. Complotypes in Blacks.
13. Kawaguchi H,*Klein J; Tübingen: Cloning of C4 and 21 hydroxylase genes of the chimpanzee.
14. Georgatsou E, Tosi-Couture E, Henry M, *Meo T, Tosi M; Paris: Exon-intron organization of the entire murine C4 and C4-SLP genes.
15. *Ghanem N, Lobaccaro JM, Sultan C, Lefranc G; Montpellier: Factor B gene polymorphism: a new Taq I restriction site associated to BF*Fa alleles.
16. *Gorgi Y, Arnold D, Uring-Lambert B, Bardi R, Ayed K, Hauptmann G.  Analysis of the genetic polymorphism of factor B, C2, C4A and C4B in 22 Tunesian families.
17. *Halasa J.  Polymorphism of the fourth component of human complement (C4) in the Polish population.
18. *Henke J.  Hint for the transmission of a silent allele at the C6 locus.
19. Herrmann D, *Schneider PM, Kaufmann T, Stradmann-Bellinghausen B, Sodetz JM, Rittner C; Mainz: Restriction fragment length polymorphism of the human complement C8 beta gene.
20. *Jürgens R, Schädlich HJ, Karbe H, Nekic M, Steuer M, Siemens I, Mauff G.  Association of MHC-related complement components BF, C2, and C4 with the course of disease in multiple sclerosis.
21. * Kaufmann T, Kytzia HJ, Rittner C. Rapid and standardized quantification of hemolytic activity of the fourth component of human complement (C4).
22. *Lévi-Strauss M, Meo T; Paris: In vitro translation of RD messengers RNA.
23. *Lokki ML, Koskimies S. BF F subtyping and distribution in the Finnish MHC haplotypes.
24. *McLean RH, Giles C, Yu CY, Campbell RD, Bias WB, Baltimore: Reversed restriction sites for the C4 isotypic and Rodgers(1)/Chido(1) regions on two hybrid C4 genes.
25. *Mizutani K, Nishimukai H, Kawata N, Iwahashi K, Tsunekawa K, Shinomiya T,  Kitamura H. C6 and C7 in Japanese patients with Buerger's disease.
26. *Morel Y, Bristow J, Gitelman SE, Shi Y, Miller WL; Lyon: Another duplicated gene lies on the DNA strand opposite from that encoding the C4 and P450c21 genes.
27. * Moulds JM, Arnett FC, Hamilton RG. A novel immunoassay for the quantitation of C4A and C4B gene products.
28. *Nishimukai H, Maruyama I, Takenaga S, Kitamura H, Mizutani K, Shinomiya T, Suzuki K, Matsumoto H. An additional factor B variant in Japanese.
29. *Nishimukai H, Nakanishi I, Kitamura H, Iida N, Takeuchi Y, Mizutani K, Shinomiya T. BF, C6 and C7 polymorphisms in japanese patients with chronic glomerulonephritis.
30. *Nürnberger W, Michelmann I, Wahn V, Tedesco F; Düsseldorf: C8 alpha-gamma polymorphism and C8 hemolytic activity in five siblings with C8ß deficient individuals.
31. *Orren A, Wallace ME, Hobart MJ, Lachmann PJ; Galway: C6 polymorphism and C6 deficiency in site-strains of the mutation-prone Peru-Coppock mice.
32. *Plum G, Krickeberg H, Bendick C, Rasokat H, Mauff G.  MHC-coded complement allotypes in AIDS-Kaposi sarcoma, AIDS related complex/WR5 and in normal controls.
33. Rittner C, *Notghi A, Gutfreund K, Rossol S, Weber C, Everke P, Stradmann B, Hüppner A, Ramadori G, Schneider PM, Hess G. C4A deficiency, a genetic risk factor for HIV infection.
34. *Rogde S, Mevag B, Teisberg P, Olaisen B, Sodetz JM; Oslo: Formal genetics, population genetics and linkage relations for a C8 beta chain RFLP.
35. * Rogde S, Teisberg P, Olaisen B. C8A and C8B polymorphisms in Norway.
36. Santamaria J, *Taborda De Messias I, Ragiotto A, Almeida NP, Mauff G. Complement C2, BF, and C4 allotypes in leprosy and healthy controls from Brazil.
37. *Schlaphoff T, Du Toit E, Oudshoorn M. C4 polymorphism in South African populations.
38. Schlaphoff T, Sarembock B, Du Toit ED, *Martell R, May R, Kalla A, Meyers OL. Polymorphism of C4A and C4B in South African populations with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
39. *Schneider PM, Everke P, Susemichel-Hüppner A, Stradmann-Bellinghausen B, Brackertz D, Rittner C. Association of chronic polyarthritis with complement C4 and HLA-DR alleles.
40. *Segurado OG, Gongora R, Regueiro JR, Arnaiz-Villena A.  A simple and highly sensitive technique for simultaneous semiquantitative detection of native and activated C2.
41. *Segurado OG, Iglesias-Cadarrubios P, Vicario JL, Arnaiz-Villena A. BF S is not split and BF Fa is found to be associated to FC31 and FC30 by isoelectic focusing and DNA analysis.
42. Snider JV, Kaufman KM, Sodetz JM. Structural analysis of the human C8A gene and its linkage to C8B.
43. *Spilliaert R, Palsdottir A, Arnason A. Analysis of the C4 gene in three species of baleen whales, Fin (Balaenoptera physalus), Sei (B. borealis) and Minke whales using a human cDNA probe.
44. *Staneková D, Starsia Z.  Distribution of BF, C4 and C3 allotypes in Slovak.
45. Stoppa-Lyonnet D, Carter P, Meo T, *Tosi M; Paris: Partial deletions and duplications in C1-inhibitor genes of Hereditary Angioedema patients are promoted by unusual clusters of repetitive Alu sequences.
46. *Suzuki K, Muto S, Cey-Bert G, Matsumoto H.  BF Fb1 characterizes some Mongoloid populations.
47. *Suzuki K, O'Neill GJO, Numano F, Matsumoto H.  Duplicated gene products and hybrid gene product at C4 loci.
48. *Taborda de Messias I, De Queiroz Telles Filho F, Reis A, Mauff G. Association of MHC class III complement components C2, BF, C4 with Brazilian paracoccidioidomycosis.
49. Tokunaga K, Zhan W, Kay PH, Dawkins RL.  Two ancestral MHC haplotypes carrying duplicated C4A genes.
50. Urbanetz L, *Taborda de Messias I, Santamaria J, Brenden M, Siemens I, Mauff G. Allotypes of C2, BF and C4 in patients with Chagas' disease from Brazil.
51. Volanakis JE, Schaffer F, Palermos J, Zhu ZB, Barger BO, Cooper MD. 

Polymorphisms of MHC class III complement genes in individuals with common variable immunodeficiency (CVID) and IgA-deficiency (IgA-D).
52. *Weidinger S, Schwerd W, Patutschnick W, Schwarzfischer F. Further evidence for a properdin factor B null allele.
53. *Würzner R, Nitze R, Götze O; Göttingen: Detection of C7 allotypes by two sandwich ELISA.
54. *He Ye-Bing, Jing Zhi-xin, Shao Bin-yang, Zhao Xiu-Zhu.  Determination of genetic polymorphism of complotypes and GLO in patients with insulin-dependent diabetes mellitus (IDDM) of Wuhan district of China.
55. * Zhou M, Larsen B; Newfoundland: Factor H polymorphism, typing by isoelectric focusing and immunoblotting: No association with rheumatoid arthritis.
56. * Zhou M, Larsen B. A new polymorphic variant of human complement factor I.
57. *Yao Zhu, Wang Ce, Tian Yan-Wu, Wu Feng, Zhao Xiu-Zhu.  Investigation of MHC class III (complotype) of Han Chinese nationality in the Hubei area.

Rittner C, Schneider PM. (1989) Complexity of MHC class III genes and complement polymorphism. Immunol. Today 10: 401-403 

Rittner C, Hauptmann G, Mauff G, Schneider PM (1990) Proceedings of the VIth Complement Genetics Workshop and Conference. Complement Inflamm. 7: 173-314